Beta-CrossLaps (β-CTX), also known as beta C-terminal telopeptides, have been designated as reference bone turnover markers (BTMs), together with Procollagen Type I N-terminal propeptide (PINP), in blood by the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). 

Following the recent launch of our PINP antibody products, we are pleased to introduce eight monoclonal β-CTx antibodies under Cat. #4BT1. With the addition of CX14, CX21, CX23, CX26, CX39, CX50, CX52, and CX80, our bone metabolism portfolio now includes osteocalcin (Cat. #4OC8), β-CTx (Cat. #4BT1), and PINP (Cat. #4PIA7), enabling customers to develop comprehensive bone metabolism panel assays. 

These eight antibodies were derived from mice and rabbits using a synthetic EKAH(betaD)GGR peptide conjugated with bovine serum albumin as the immunogen. Rabbit antibodies were obtained in recombinant format, while mouse antibodies were produced from hybridoma cell lines in vitro. By providing antibodies from different species and using various antibody formats, we enable our customers to develop assays on various platforms, meeting your diverse needs. 

Our new products are designed for the development of highly sensitive and quantitative β-CTx immunoassays. One of the recommended pairs, CX50 (capture) – CX21 (detection), achieves a limit of detection (LoD) of 11,3 pg/ml. Assays utilizing the recommended MAb pairs have also demonstrated a strong correlation with the commercially available Elecsys® β-CrossLaps/serum ECLIA, with Pearson’s correlation coefficients reaching up to 0.98. In addition, the cross-reactivity of anti-β-CTx antibodies with the α-CTx-ovalbumin conjugate has been evaluated. 

Technical details are available in the product Cat. #4BT1 Data Sheet and Beta-CrossLaps (β-CTx) Technote. 

For more information or to place an order, please contact your regional Sales Team. 

Please note: Product availability may vary by region.