Alpha-fetoprotein (AFP)

Alpha-fetoprotein (AFP) has been routinely applied to the screening and clinical diagnosis of Hepatocellular Carcinoma (HCC). AFP levels reflect tumor size and correlate with the disease's progression, making them a sensitive indicator for monitoring treatment effects and prognosis

AFP is a single-chain glycoprotein with a molecular weight of about 70 kDa. It is one of the major proteins in fetal circulation and is initially produced by the liver and yolk sac of the fetus. In adults, AFP concentrations are elevated in malignant diseases (tumors) and pregnancy. Elevated AFP levels have also been observed in some non-hepatic malignancies. For example, AFP levels can increase when a large number of liver cells are damaged due to hepatitis, chronic liver disease, or malignant tumors, especially teratoma, and gastrointestinal cancer.

Hytest offers two monoclonal antibodies under the Cat. # 4F16 that can be used as a pair in sandwich immunoassay (capture-detection): 4A3cc - 5H7cc.

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