New monoclonal antibodies specific to epitope 24-40 of human cardiac Troponin I TechNotes

The region 24-40 aar of cardiac troponin I (cTnI) is a perspective target for monoclonal antibodies due to the several reasons. The first 32 aar of the cTnI are not present in skeletal isoforms of the protein. Of the following 8 aar residual (33-40) 3 are also unique to the cardiac isoform, which increases the probability of obtaining of highly-specific antibodies without cross-reaction with the two skeletal isoforms of troponin I. In contrast to the most of the central part of cTnI, the region 24-40 aar is not hindered by the other components of troponin complex and is almost not affected by the action of autoantibodies neither. Moreover, our recent studies have shown that even though cTnI is prone to proteolytic degradation, fragment 24-40 of cTnI molecule is rather stable even at the late times after acute myocardial infarction (AMI). All these features make the antibodies, specific to the 24-40 aar of cTnI, a perspective tool for reliable immunochemical measurements of cTnI concentration.

Products:

4T21 Monoclonal mouse anti-cardiac troponin I (cTnI)
4T21cc Monoclonal mouse anti-cardiac troponin I (cTnI), in vitro
RC4T21 Recombinant chimeric anti-cTnI MAb (Cat.# 4T21)
4TC2 Monoclonal mouse anti-human native cardiac troponin complex
RC4TC2 Recombinant chimeric anti- human native cardiac troponin complex MAb (Cat.# 4TC2)